Digestive System
As food enters the body it goes through a journey to transport all the nutrients necessary for all other body systems to function properly. Several organs simultaneously work together to maintain a nutritional balance and expel unnecessary components.


Key Organs
Mouth:
The mouth is where digestion begins using both mechanical and chemical elements to break down food. The mechanical properties consist of chewing and ingestion through our teeth and tongue. Through mastication (chewing) the teeth crush food into smaller pieces in which the tongue can position and push down the throat. Our teeth consist of incisors (sharp front teeth) to cut, canines (pointed) to tear, and molars (flat) to crush the food. Saliva is the main component of chemical breakdown. This is produced from three glands in the mouth: parotoid, sublingual, and submandibular. In saliva there consists of enzymes such as amylase (breaks down starch) as well as lysozymes (protect from infections), mucus, and bicarbonate. As the mouth chews the food is formed into a bolus which can be pushed down the pharynx and esophagus.
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Pharynx and esophagus:
The pharynx is a muscular tube that has three parts connecting it from the mouth to the esophagus. The upper portion is the nasopharynx which contains a soft palate to prevent food from backing up or entering nasal cavities. The middle portion is the oropharynx and the bottom that connects to the esophagus and trachea is the laryngopharynx. The epiglottis is used to cover the trachea and prevent food from entering it and muscles push the bolus down into the esophagus. The esophagus transports food all the way to the stomach. It contains mucosa and smooth muscles to secrete mucus and push food down. The consistent contractions of muscles in the esophagus is called peristalsis. Finally, the ring or valve that prevents acid reflux is the lower esophageal sphincter.
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Stomach:
The stomach uses both mechanical and chemical breakdown of food to digest it. First smooth muscle tissue churn the food through relaxing and contracting muscles. This creates the liquid substance chyme that can be absorbed by other organs. The chemical breakdown is led by gastric juices containing hydrochloric acid, pepsin, and mucus. These break down proteins and kill harmful pathogens. In addition, the mucus acts as a barrier for mucosal cells preventing them from damage from the acids. The chyme is emptied into the small intestine through the pyloric sphincter in which high fat meals are emptied slowly while carbohydrate and liquid rich meals empty quickly. Hormones in the small intestine like secretin and CCK tell the stomach to slow down the emptying of chyme.
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Small intestine:
This is the longest part of the digestive tract. The first part of the small intestine, the duodenum contains pancreatic juices as well as bile to break down carbs, proteins, and fats. The middle portion, the jejunum, contains villi and microvilli to increase surface area for nutrient absorption. In the final portion, the ileum recycles bile acids back to the liver.
Large intestine:
The large intestine or colon is the smaller tube connecting the small intestine to the rectum. The large intestine absorbs water, electrolytes, and vitamins. This is also where fermentation occurs. Bacteria break down sugars and complex carbohydrates through anaerobic respiration producing energy. Finally, the large intestine forms feces as well as stores them in the rectum.
Rectum and anus:
The rectum is where feces are stored and the anus is where it is expelled through a process called defecation. The anus contains muscles to control the release of waste.
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Absorption of nutrients
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Liver:
The liver is found on the right side of the abdomen and produces bile. Bile is important for emulsifying fats. In addition, the liver can convert glucose to glycogen and break down fats and proteins. Nutrients such as glycogen as well as iron and vitamins are stored in the liver. Finally, the liver detoxifies the blood as well from alcohol, drugs, and waste.
Gallbladder:
The gallbladder is pear shaped and can be found below the liver. It is used to store the bile produced from the liver. It absorbs water and electrolytes to concentrate the bile and when fatty food enters the small intestine the gallbladder contracts to release the bile.
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Pancreas:
Pancreas are located underneath the stomach. It produces different enzymes such as amylase, lipase, protease, and bicarbonate that can break down food. In addition, pancreas have hormonal effects as well. Insulin, used to decrease blood sugar by storing glucose as glycogen in cells, and glucagon, used to increase blood by promoting the release of glucose from the liver, are both produced by the pancreas.
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Gut Microbiome
Gut Microbiome
The gut microbiome consists of the trillions of microorganisms that live in the digestive tract. The large intestine contains a large portion of the microbes. They control how the body digests food, absorbs nutrients, and interacts with the immune system. A key to a healthy gut microbiome is balance. This means a diverse and abundant population of microbes.
Undigested carbohydrates:
The gut microbiome assists with digestion of fiber and some forms of starch. They ferment these molecules into SCFA (short chain fatty acids). One example is butyrate which is an energy source for cells as well as has anti-inflammatory properties.
The gut microbiome also produces essential nutrients such as:
1. B vitamins
Biotin, folate, and vitamin B12 all are essential for energy production and the production of red blood cells
2. Vitamin K
Vitamin K is necessary for blood clotting and bone health
3. Amino acids and fatty acids
Function with immune system
Gut microbes outcompete harmful pathogens for nutrients and space and produce antimicrobial compounds. Gut microbiomes prevent autoimmune diseases through presentation of non-harmful substances, such as food, to immune cells.
How the gut microbiome affects health:
The gut microbiome synthesizes short chain fatty acids which can regulate fat storage and glucose metabolism. In addition, an imbalance in the gut microbiome will result in chronic inflammation. Finally, the gut microbiome is linked to the brain through the gut-brain axis. This influences mood and anxiety as well as depression can be linked to an unhealthy gut microbiome.
Nutrition
Prebiotics and probiotics:
Fiber is a common form of prebiotics. These prebiotics feed beneficial bacteria in the gut microbiomes. They can be found in foods such as:
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Whole grains
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Legumes
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Fruits and vegetables
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Nuts and seeds
Probiotics:
Probiotics are beneficial bacteria. They help restore balance in the gut microbiome. Common sources of probiotics include:
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Yogurt
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Pickles
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Kefir
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Supplements
Polyphenols:
Polyphenols have several antioxidant properties. This means they prevent damage to different cells and tissues. In addition, polyphenols stimulate growth of beneficial bacteria. Common sources include:
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Berries
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Dark chocolate
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Green tea
The most important factor is hydration. Hydration facilitates the proper movement of food and supports mucosal layers through our digestive systems.
Avoid processed foods as well as artificial sweeteners. Studies have shown processed foods promote harmful bacteria and artificial sweeteners lead to glucose intolerance.
Common Digestive Diseases

GERD:
Gastroesophageal Reflux disease is a chronic condition in which stomach acid irritates the lining of the esophagus. This can lead to heartburn and regurgitation. This is caused by the lower esophageal sphincter becoming weak or hiatal hernia. Hiatal hernia is where the stomach pushes into the diaphragm making it easier for acid to go into the esophagus.
Symptoms:
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Heartburn (burning in chest0
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Acid regurgitation
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Chronic cough or sore throat
IBD:
Inflammatory bowel disease has two conditions. One is Crohn’s disease and the other is ulcerative colitis. Crohn’s disease commonly affects the small intestine and colon causing diarrhea, weight loss, and abdominal pain. Ulcerative colitis affects the colon and rectum. Often this can lead to chronic diarrhea with blood. Both can be due to abnormal immune responses and disrupted gut microbiomes.
Gallstones:
These are hardened deposits of bile that form in the gallbladder where it is usually stored. This is caused from excess cholesterol or impaired motility in the gallbladder. Risks include obesity and aging factors.
Symptoms:
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Pain in upper right abdomen
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Vomiting
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Jaundice (yellowing in eyes or skin)
Surgery is the most common treatment
Hepatitis:
Hepatitis is the inflammation of the liver. This can be caused by viruses such as hepatitis A, B, or C. These are transported by fluids such as blood, water, sexual contact, or even mother to baby at childbirth.
Symptoms:
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Fatigue
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Abdominal pain
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Dark urine
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Nausea
Sources
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National Institute of Diabetes and Digestive and Kidney Diseases. Your Digestive System & How It Works. U.S. Department of Health and Human Services, 1 Mar. 2017, https://www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works.
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“Chapter 5: Digestion and Absorption.” Nutrition Essentials, Maricopa Open Digital Press, https://open.maricopa.edu/nutritionessentials/chapter/chapter-5-digestion-and-absorption/.
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Sciencenewstoday.org. “What Is the Digestive System? Functions, Organs, and Disorders Explained.” Science News Today, https://www.sciencenewstoday.org/what-is-the-digestive-system-functions-organs-and-disorders-explained.
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“Digestive System Diseases.” Verywell Health, https://www.verywellhealth.com/digestive-system-diseases-7375274.
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“How Your Gut Health Impacts Your Body.” EatingWell, 4 Mar. 2024, https://www.eatingwell.com/how-your-gut-health-impacts-your-body-8695122.
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“Best Foods for Gut Health.” Real Simple, https://www.realsimple.com/best-foods-for-gut-health-7098940.
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Wikipedia contributors. “Inflammatory Bowel Disease.” Wikipedia, Wikimedia Foundation, https://en.wikipedia.org/wiki/Inflammatory_bowel_disease.
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“Nutrition for Digestive Disorders.” Nutrition.gov, https://www.nutrition.gov/topics/diet-and-health-conditions/digestive-disorders.
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Images:
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On the human digestive system:
"Digestive system of Humans." BYJU’S – Biology, BYJU’S, www.byjus.com/biology/human‑digestive‑system/. -
On common digestive issues and prevention:
"The Most Common Digestive Issues and How to Prevent Them." LivGastro – Patient Education, LivGastro, www.livgastro.in/patient_education/the‑most‑common‑digestive‑issues‑and‑how‑to‑prevent‑them/.
